Reproduction Abstracts

Early embryo development is an exquisitely sensitive period of the developmental continuum, profoundly influencing neonatal and adult health. Maternal and paternal hyperglycaemia is associated with long-term health complications including increased risk of miscarriage, altered birth weight, and increased incidence of diabetes and metabolic syndrome in adult life. The mechanisms underlying this intergenerational transmission of disease remain unclear. New evidence has implicate...

Research conducted in recent years has led to great advances in our understanding of the participation of cGMP in meiosis. It is clear that increased intra-oocyte concentrations of cGMP inhibit meiosis in mouse models. Like cAMP, cGMP may also have a meiotic stimulatory function, possibly via cGMP/PKG. Abattoir derived gilt porcine ovaries were collected, antral follicles aspirated and oocytes collected and cultured in TCM-199+3 mg/ml BSA. Natriuretic peptide receptor 2 (N...